N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE

N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE - Names and Identifiers

Name	N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE
Synonyms	WAY-213613 N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE
CAS	868359-05-1

N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE - Physico-chemical Properties

Molecular Formula	C16H13BrF2N2O4
Molar Mass	415.19
Solubility	Soluble in DMSO
Storage Condition	-20℃
Use	WAY-213613 is a potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). WAY-213613 exhibits no activity towards ionotropic and metabotropic glutamate receptors.
Target	Human EAAT2 Human EAAT3 Human EAAT1

N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE - Reference

Reference

1: Karatas-Wulf U, Koepsell H, Bergert M, Sönnekes S, Kugler P. Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells. Neuroscience. 2009 Jul 7;161(3):794-805. doi: 10.1016/j.neuroscience.2009.04.017. Epub 2009 Apr 11. PubMed PMID: 19364521.
2: Dunlop J, McIlvain HB, Carrick TA, Jow B, Lu Q, Kowal D, Lin S, Greenfield A, Grosanu C, Fan K, Petroski R, Williams J, Foster A, Butera J. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13. PubMed PMID: 16014807.

N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.409 ml	12.043 ml	24.085 ml
5 mM	0.482 ml	2.409 ml	4.817 ml
10 mM	0.241 ml	1.204 ml	2.409 ml
5 mM	0.048 ml	0.241 ml	0.482 ml

Last Update：2024-01-02 23:10:35

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N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE

N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE

N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE

CAS: 868359-05-1

Molecular Formula: C16H13BrF2N2O4

N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE - Names and Identifiers

N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE - Physico-chemical Properties

N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE - Reference

N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE - Preparation solution concentration reference

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